The model has decided to end her partnership with the brand after three years of designing for the British retailer, reports Contactmusic.
Label boss Philip Green dismissed rumours that Moss's departure was caused by a rift between the two, stating: "There have been no dramas and we don't need a new muse. There is only one Kate and we are not looking for a replacement.
"Kate has done 14 collections with us. It has been fantastic for us and fantastic for her, but they take more and more time and she cannot do this full-time any more because she has other commitments."
Moss is due to unveil her final collection for Topshop in October.
