The musician, who was best known for the 1975 hit 'Poetry Man', passed away this morning in Edison, NJ, her rep Rick Miramontez confirmed to The AP.
Achieving her most notable success in the 1970s, Snow collaborated with many of the era's most popular musicians, including Paul Simon and Jackson Browne.
She was also a frequent musical guest in the early years of Saturday Night Live, appearing on the programme's second-ever telecast, and later returning with friend Linda Ronstadt to duet on 'The Shoop Shoop Song (It's In His Kiss)' in 1979.
Snow gave birth to disabled daughter Valerie in 1975, and largely shunned the spotlight in order to care for the child. Valerie died in 2007 at 31 years old.
In recent years, the 'Gone at Last' musician was plagued with a series of health problems, including suffering both a stroke and congestive heart failure.
She was reportedly working on her first new studio LP in eight years at the time of her death.
Her long-time manager Sue Cameron described Snow's passing as "incalculable", adding: "Phoebe was one of the brightest, funniest and most talented singer-songwriters of all time and, more importantly, a magnificent mother to her late brain-damaged daughter, Valerie, for 31 years. Phoebe felt that was her greatest accomplishment."
