The family-oriented comedy pushed its two-week total to $89.8 million and showed staying power in theaters with a decline of 35 percent from last week's debut of nearly $48 million for its producers at DreamWorks Animation.
The relatively small drop, compared to other major releases that often see ticket sales fall 50 percent or more, has DreamWorks Animation hoping "Megamind" can hold its own against the widely anticipated "Harry Potter and the Deathly Hallows: Part 1" when it debuts in theaters next weekend.
"We're seeing lots of momentum with kids and especially young boys," DreamWorks Animation global marketing chief Anne Globe said, adding that the company expects "Megamind" to continue performing well in theaters equipped with 3D.
The new "Harry Potter" will not be show in 3D.
In second place over the weekend was runaway train movie "Unstoppable," starring Denzel Washington and Chris Pine. It pulled in $23.5 million and was the top-grossing new release, pleasing its distributor 20th Century Fox.
The fast-paced thriller generally earned good reviews from both critics and positive response from fans, Fox said, which is rare in theaters these days.
"Unstoppable" debuted in about 3,200 theaters, for an average of $7,300 per location. "Megamind" pulled in $7,600 per venue in approximately 3,900 locations.
In its second week in theaters, Warner Bros. comedy "Due Date," starring Robert Downey Jr., dropped one position to the No. 3 slot on box office charts with $15.5 million, or $4,600 per theater in more than 3300 locations.
Sci-fi thriller "Skyline" was No. 4 with $11.7 million, while romantic comedy "Morning Glory" rounded out the top 5 with $9.6 million, a disappointing opening with major stars like Harrison Ford and Diane Keaton working alongside Rachel McAdams.
Director Tyler Perry's "For Colored Girls" fell to the No. 6 spot with a 65 percent drop in ticket sales to a total $6.8 million. That figure pushed its cumulative box office to just under $31 million in two weeks.
Rounding out the top 10 in descending order were four holdovers from recent weeks, "Red," "Paranormal Activity 2" "Saw 3D" and "Jackass 3D."
"Megamind," "Morning Glory," "Paranormal Activity 2" and "Jackass 3D" were all distributed by Paramount Pictures, a unit of Viacom Inc.. "Megamind" was produced by DreamWorks Animation.
"Skyline" was released by Universal Pictures, a unit of General Electric's NBC Universal media division, and "Unstoppable" by 20th Century Fox is a division of News Corp. "For Colored Girls" and "Saw 3D" were released by Lions Gate, and "Red" by privately held Summit Entertainment.
