Set in ancient Greece, "Immortals" scored $32.2 million in weekend receipts, pushing it past Sandler's "Jack and Jill," in which he plays both a successful Los Angeles advertising executive and his needy twin sister Jill.
The comedy came in second with $25 million, according to monitor Exhibitor Relations.
Animated kids' romp "Puss in Boots," last week's leader, took third place with $24.7 million. The flick features voice work by Antonio Banderas, Salma Hayek, Zach Galifianakis and Billy Bob Thornton.
In fourth was "Tower Heist," with an all-star cast led by Eddie Murphy -- who quit as Oscars host last week after a row over anti-gay comments by the film's and the Oscars' producer Brett Ratner -- at $12.7 million.
It was trailed by Clint Eastwood's "J. Edgar," which stars DiCaprio as late FBI director J. Edgar Hoover and raked in $11.2 million.
Comedy sequel "A Very Harold and Kumar 3D Christmas" fell to sixth place, with $5.9 million, besting futuristic thriller "In Time" starring Justin Timberlake and Amanda Seyfried at $4.1 million.
Dropping to the eighth spot was "Paranormal Activity 3," with $3.6 million over the weekend but an impressive total of $100.8 million over four weeks in theaters.
A remake of the hit 1980s dance romp "Footloose" slipped to ninth at $2.7 million, ahead of the boxing robots of "Real Steel," with the Disney hit for children starring Hugh Jackman taking in $1.9 million. (AFP)
