The 22-year-old will appear completely naked in an eight-page spread for the publication's September edition, reports E! Online.
Lowe has been outspoken about her uncharacteristically "curvy" modelling body, claiming that she is "proud" to bring diversity to the industry.
"I'm really proud of being the poster girl for curves, I'm proud of my shape. I think that what I'm aiming for is the return of the supermodel. We need to have real characters that women can relate to and look up to," she told The Mail On Sunday.
Lowe has also admitted to having body issues in the past, revealing that it is only in recent months that she has come to accept the fact that she isn't skinny.
The star has also said that she would like to move into acting as a Bond girl.
